Wonders

Key research papers on telehealth and telemedicine

Effectiveness reviews, barriers to adoption, patient satisfaction and the COVID-19 expansion: the most-cited telehealth research with search strings.

Data from OpenAlex, retrieved September 21, 2026

In short

Telehealth research existed for decades as a niche before 2020: Ekeland, Bowes and Flottorp (2010) reviewed the reviews, and Kruse and colleagues catalogued barriers (2018) and patient satisfaction (2017). Publication rose from 1,718 titles in 2019 to 4,960 in 2021 after services moved online almost overnight. Snoswell et al. (2023) is the synthesis to start from: 38 meta-analyses across ten disciplines, finding telehealth as effective as usual care or better. Equity of access is the theme that now runs through the field.

How the literature is organised

Before 2020, telehealth research was organised around three questions. Does it work? Ekeland, Bowes and Flottorp (2010) is the systematic review of reviews from that era. Will clinicians and patients use it? Hu et al. (1999) tested the technology acceptance model on physicians in Hong Kong public hospitals and found perceived usefulness a significant determinant of intention while perceived ease of use was not — a result worth knowing before you build a survey around both. Kruse et al. (2018) reviewed 30 articles and counted 33 distinct barriers to adoption worldwide, led by technically challenged staff (11%), resistance to change (8%) and cost (8%). Kruse et al. (2017) screened 2,193 articles for patient satisfaction and found improved outcomes, preference for the modality, ease of use, low cost, better communication and less travel time accounting for 61% of the factors mentioned. Where is it going? Dorsey and Topol (2016) describe telehealth evolving from the clinic to the home.

The pandemic turned a specialist topic into a mainstream one. Hollander and Carr (2020), Smith et al. (2020) and Wosik et al. (2020) argued the case as it happened; Mann et al. (2020) supplied the numbers from one New York health system, where daily telemedicine urgent care visits went from 102.4 to 801.6 between early March and mid-April 2020. Monaghesh and Hajizadeh (2020) reviewed the early evidence and found just eight studies meeting their criteria, which is worth remembering when that review is cited as though it settled something.

Main debates

The main argument since 2021 has been about equity, and the listed studies make it concrete. Rodriguez et al. (2021), across 231,596 visits at one integrated health system, found patients over 65, Black, Hispanic, Spanish-speaking or in low-broadband areas significantly less likely to have a video rather than a telephone visit — and found that practices (38%) and clinicians (26%) drove far more of the variation in video use than patients did (9%). Chang et al. (2021) found the same split on the provider side in New York City: small primary care practices in high social vulnerability areas were nearly twice as likely to use the telephone as their main modality, and about half as likely to use video, as those in low-vulnerability areas. Patel et al. (2021), across 16.7 million enrollees, found telemedicine accounting for 30.1% of visits during the pandemic, lower in communities with higher poverty rates, and ranging from 68% of endocrinologists to 9% of ophthalmologists.

A second debate concerns payment and regulation after emergency rules expire. Shaver (2022) covers the US position; the OECD (2023) reports that the boom preserved access and continuity of care but also exposed the limits of remote care and raised concerns that some teleconsultations are low-value.

Where recent work is heading

Work has shifted from "can we?" to "when should we?". Snoswell et al. (2023) consolidate clinical effectiveness and note how discipline-specific the evidence is. Butzner and Cuffee (2021) review 15 studies of rural US communities and report acceptability, lower costs and better recruitment and retention of clinicians. Barbosa et al. (2021) conclude that telemedicine has improved access across a wide range of conditions and has addressed geographical barriers, but less so social ones. Omboni et al. (2022) list what large-scale implementation still needs: legislation, licensing, privacy protection, reimbursement plans, practical clinical guidelines and integration with conventional services. Bitar and Alismail (2021) make the honest point about the pandemic literature — limited evidence on effectiveness.

Newer angles include environmental impact: Purohit, Smith and Hibble (2021) found every identified study reporting a reduced carbon footprint, mostly from avoided travel, with savings ranging from 0.70 to 372 kg CO2e per consultation and highly context-specific. For nursing students, competencies for telehealth practice and patient experience are tractable thesis topics.

Most-cited foundational papers

Published before 2021 and ranked by how often later work cites them. Read the abstract of each and the full text of the three or four closest to your question. Citation count measures attention, not quality, so treat this as a map of what the field has argued about rather than a ranking of what is true.

  1. 1
    Virtually Perfect? Telemedicine for Covid-19

    Judd E. Hollander, Brendan G. Carr (2020). New England Journal of Medicine.

    Cited by 3,099doi:10.1056/nejmp2003539

  2. 2
    The role of telehealth during COVID-19 outbreak: a systematic review based on current evidence

    Elham Monaghesh, Alireza Hajizadeh (2020). BMC Public Health.

    Cited by 1,958Open accessdoi:10.1186/s12889-020-09301-4

  3. 3
    Examining the Technology Acceptance Model Using Physician Acceptance of Telemedicine Technology

    Paul J. Hu and 3 others (1999). Journal of Management Information Systems.

    Cited by 1,958doi:10.1080/07421222.1999.11518247

  4. 4
    Telehealth for global emergencies: Implications for coronavirus disease 2019 (COVID-19)

    Anthony C Smith and 6 others (2020). Journal of Telemedicine and Telecare.

    Cited by 1,892Open accessdoi:10.1177/1357633x20916567

  5. 5
    Evaluating barriers to adopting telemedicine worldwide: A systematic review

    Clemens Scott Kruse and 5 others (2018). Journal of Telemedicine and Telecare.

    Cited by 1,837Open accessdoi:10.1177/1357633x16674087

  6. 6
    Telehealth transformation: COVID-19 and the rise of virtual care

    Jedrek Wosik and 11 others (2020). Journal of the American Medical Informatics Association.

    Cited by 1,656Open accessdoi:10.1093/jamia/ocaa067

  7. 7
    COVID-19 transforms health care through telemedicine: Evidence from the field

    Devin M Mann and 4 others (2020). Journal of the American Medical Informatics Association.

    Cited by 1,460Open accessdoi:10.1093/jamia/ocaa072

  8. 8
    Telehealth and patient satisfaction: a systematic review and narrative analysis

    Clemens Scott Kruse and 5 others (2017). BMJ Open.

    Cited by 1,422Open accessdoi:10.1136/bmjopen-2017-016242

  9. 9
    State of Telehealth

    E. Ray Dorsey, Eric J. Topol (2016). New England Journal of Medicine.

    Cited by 1,227doi:10.1056/nejmra1601705

  10. 10
    Effectiveness of telemedicine: A systematic review of reviews

    Anne G. Ekeland, Alison Bowes, Signe Flottorp (2010). International Journal of Medical Informatics.

    Cited by 1,215Open accessdoi:10.1016/j.ijmedinf.2010.08.006

Most-cited papers since 2021

Primary studies and conceptual papers from 2021 onwards. A paper published in 2024 has had a few years to accumulate citations where the works in the section above have had decades, so compare these counts with each other rather than with the ones above.

  1. 1
    Telemedicine for healthcare: Capabilities, features, barriers, and applications

    Abid Haleem and 3 others (2021). Sensors International.

    Cited by 1,663Open accessdoi:10.1016/j.sintl.2021.100117

  2. 2
    Telehealth Benefits and Barriers

    Shilpa N. Gajarawala, Jessica N. Pelkowski (2021). The Journal for Nurse Practitioners.

    Cited by 1,010Open accessdoi:10.1016/j.nurpra.2020.09.013

  3. 3
    The State of Telehealth Before and After the COVID-19 Pandemic

    Julia Shaver (2022). Primary Care: Clinics in Office Practice.

    Cited by 871Open accessdoi:10.1016/j.pop.2022.04.002

  4. 4
    Variation In Telemedicine Use And Outpatient Care During The COVID-19 Pandemic In The United States

    Sadiq Y. Patel and 5 others (2021). Health Affairs.

    Cited by 470Open accessdoi:10.1377/hlthaff.2020.01786

  5. 5
    The COVID-19 Pandemic and the Future of Telemedicine

    OECD (2023). OECD Health Policy Studies.

    Cited by 440doi:10.1787/ac8b0a27-en

  6. 6
    Differences in the use of telephone and video telemedicine visits during the COVID-19 pandemic

    Jorge A. Rodriguez et al. (2021). The American Journal of Managed Care.

    Cited by 423Open accessdoi:10.37765/ajmc.2021.88573

  7. 7
    Rapid Transition to Telehealth and the Digital Divide: Implications for Primary Care Access and Equity in a Post‐COVID Era

    Ji E. Chang and 5 others (2021). The Milbank Quarterly.

    Cited by 407Open accessdoi:10.1111/1468-0009.12509

  8. 8
    The worldwide impact of telemedicine during COVID-19: current evidence and recommendations for the future

    Stefano Omboni and 20 others (2022). Connected Health.

    Cited by 384Open accessdoi:10.20517/ch.2021.03

Recent reviews and meta-analyses

The fastest way into a literature. A good review gives you the structure of the field, a reference list to mine and, in its limitations section, the gaps other researchers have already spotted.

  1. 1
    The clinical effectiveness of telehealth: A systematic review of meta-analyses from 2010 to 2019

    Centaine L Snoswell and 6 others (2023). Journal of Telemedicine and Telecare.

    Cited by 410doi:10.1177/1357633x211022907

  2. 2
    Telehealth utilization during the Covid-19 pandemic: A systematic review

    Salem Garfan and 18 others (2021). Computers in Biology and Medicine.

    Cited by 385Open accessdoi:10.1016/j.compbiomed.2021.104878

  3. 3
    Telehealth Interventions and Outcomes Across Rural Communities in the United States: Narrative Review

    Michael Butzner, Yendelela Cuffee (2021). Journal of Medical Internet Research.

    Cited by 340Open accessdoi:10.2196/29575

  4. 4
    The role of eHealth, telehealth, and telemedicine for chronic disease patients during COVID-19 pandemic: A rapid systematic review

    Hind Bitar, Sarah Alismail (2021). Digital Health.

    Cited by 327Open accessdoi:10.1177/20552076211009396

  5. 5
    Improving Access to Care: Telemedicine Across Medical Domains

    William Barbosa and 4 others (2021). Annual Review of Public Health.

    Cited by 318Open accessdoi:10.1146/annurev-publhealth-090519-093711

  6. 6
    Does telemedicine reduce the carbon footprint of healthcare? A systematic review

    Amy Purohit, James Smith, Arthur Hibble (2021). Future Healthcare Journal.

    Cited by 308Open accessdoi:10.7861/fhj.2020-0080

How big the literature is, and where it is published

OpenAlex indexes 48,194 works whose title matches this topic. The chart shows how many were published each year from 2000 to 2025; the current year is left out because it is incomplete.

2000: 507 works50720002001: 504 works2002: 623 works2003: 477 works2004: 471 works2005: 591 works2006: 603 works2007: 521 works2008: 627 works2009: 659 works2010: 659 works2011: 921 works2012: 848 works2013: 948 works2014: 1,046 works2015: 1,244 works2016: 1,280 works2017: 1,311 works2018: 1,530 works2019: 1,718 works2020: 3,810 works2021: 4,960 works4,96020212022: 4,578 works2023: 4,149 works2024: 4,107 works2025: 4,198 works4,1982025
Show the numbers as a table
YearWorks
2000507
2001504
2002623
2003477
2004471
2005591
2006603
2007521
2008627
2009659
2010659
2011921
2012848
2013948
20141,046
20151,244
20161,280
20171,311
20181,530
20191,718
20203,810
20214,960
20224,578
20234,149
20244,107
20254,198

Journals behind the most-cited work

Counted across the 191 most-cited works on the topic, not across everything published. Browsing recent issues of the first two or three is a reliable way to find current work that has not yet been cited much.

Sub-topics to narrow into

A thesis-sized question usually sits inside one of these, combined with a population or a setting.

How to cite these papers

Every paper above has a DOI, a part of the reference that is easy to leave out. Here is one of them, “Virtually Perfect? Telemedicine for Covid-19” (2020), in the two styles students ask about most:

APA 7th edition

Hollander, J. E., & Carr, B. G. (2020). Virtually perfect? Telemedicine for Covid-19. New England Journal of Medicine, 382(18), 1679–1681. https://doi.org/10.1056/nejmp2003539

MLA 9th edition

Hollander, Judd E., and Brendan G. Carr. “Virtually Perfect? Telemedicine for Covid-19.” New England Journal of Medicine, vol. 382, no. 18, 2020, pp. 1679–81, https://doi.org/10.1056/nejmp2003539.

Check the details against the article itself before you submit: databases, including the one behind this page, sometimes carry the online-first year rather than the volume year. Full rules and more examples are in our guides to APA, MLA, Chicago, Harvard, Vancouver and ABNT, with the rest in the citation guides. You can also format a reference from its DOI with our free citation tools.

Frequently asked questions

What is the difference between telehealth and telemedicine?

Telemedicine usually means remote clinical services between clinician and patient. Telehealth is broader and includes education, monitoring and administrative uses. Many authors use them interchangeably, so search for both; this page does.

Is telehealth as effective as in-person care?

For many conditions, yes. Snoswell et al. (2023) reviewed 38 meta-analyses published between 2010 and 2019, covering ten disciplines from cardiovascular disease to psychiatry, and found telehealth as effective as usual care or better across all of them — while saying plainly that the evidence is very discipline-specific and that more studies are needed across a wider range of services. Note too that equivalence in a trial does not guarantee equivalence for a patient without broadband or privacy at home; that is what Rodriguez et al. (2021) and Chang et al. (2021) measure.

Why are so many highly cited telehealth papers short commentaries?

Because they were published in March and April 2020, when clinicians needed a rationale for switching quickly. Hollander and Carr (2020) is a three-page perspective article. Cite these for the historical moment and use reviews and cohort studies for evidence.

How this page was made

The lists come from OpenAlex, an open index of scholarly works whose data are published under a CC0 licence, queried on September 21, 2026 for works whose title matches (telehealth OR telemedicine). Only works with a DOI are listed. Each one was checked against the publisher’s own record at Crossref or DataCite (title, year, first author, journal, volume and pages), and in three cases, where the publisher deposited no byline, against PubMed; anything OpenAlex or Crossref flags as retracted was left out, and an editor took out results that matched the words but not the subject. Citation counts are OpenAlex’s on that date and are usually lower than Google Scholar’s, which counts more kinds of document. Ranking by citations tells you what a field has relied on, not what is correct; several heavily cited papers on any topic are cited because later work disputes them. Books without a DOI are missing, which matters in fields where the founding text is a book.

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